Please help: no ability lag, ping is fine, but only about 60% of my right clicks are registering

Hi everyone, Please see title--my game is completely fine--ability lag, ping is good, and chat comes through solid--with one Major exception. When I right click (i.e. just moving around in lane), only about 65% of my clicks are going through, and mechanically, my mouse is fine (tested multiple methods, same result). Right now, it is absolutely devastating for gameplay and makes it completely unplayable. Has anyone else experienced this or know what to do to fix it? Thanks!
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