My Mouse 4 Button Keeps Unbinding

I have my mouse 4 button binded to item slot 2. On my main account (the one I'm posting on), every roughly 3-4 games at the start of the match it will randomly unbind itself and I will have to manually rebind it to item slot 2. Funny though, this issue doesn't occur on my second account. Anyone got the same problem/got any fixes?

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