Half second freeze on click while in-game

Operating System: Windows 10 Home 64-bit Processor: AMD FX-8800P Radeon R7, 12 Compute Cores 4C+8G (4 CPUs), ~2.1GHz Memory: 8192MB RAM Available OS Memory: 7128MB RAM Graphics: AMD Radeon R9 M385X So far, this issue happens no matter what champion I play as. When I click on an enemy champion to attack or to use an ability on, the game will freeze for a split second, frame rate dropping to 0 before returning to a steady 60. This doesn't happen when assisting friendly champions or when attacking towers/minions/jungle. Strangely, this didn't happen until a couple of updates ago. Any quick fixes/tips are appreciated.
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