Would it make him less frustrating to play against? I think so.
Not only do you have to aim his Q no matter what in this case, but to get the knock up, you gotta land the skillshot. No exceptions.
Not only do you have to land the skill shot in this case, but part of what makes his ranged Q more or less balanced is the cast time it has. You have a lot of extra time to flash or dash it, or hell, even to just dodge it. E-Q is just basically undodgeable by almost any means. That leads to a free ult, another free Q, and a free auto attack.
I feel it's a good place to start without directly touching any numbers.