What have masteries archieved so far?

Damage creep. Level 6 all ins are more powerful than ever in the mid lane thanks to thunderlords Tank creep. Thanks to colossus, every tank that has easy-to-land cc is now an invincible pile of bs Tank assassins. Pretty much every assassin that made place in s6 has been played somewhat tanky. Zed, Ekko, Yasuo, Fizz, Akali. Seriously though, are there even an upside to these keystones?
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