Help: I can't play Zoe.

I don't know why, but i can never land her Skillshots. I'm perfectly fine at it with pretty much every other champion, but this one, THIS ONE is a pain. I like her, whenever i land skillshots, but when i don't and i can't fight back it feels so terrible. I don't know what rune's are best, honestly, i don't know what to do in lane against Hyper Mobile champions(Zed, Akali, Yasuo) as her because if i miss, i just flat out die. How do you play this champion.
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