I'd create and enforce this rule:
If a game is lost in under 30 minutes, anyone on the losing team playing a champion with which they have less than a Rank 4 mastery is required to play 5 Normal games before they can return to Ranked play.
Get these Zuan scientists out of my ranked games. It's not the place to experiment, it's 4 other people's hour. I'd love to know why Riot favors criminals and trolls.
Edit: A new rule added based on a suggestion. **People who are auto-filled will not be subject to this restriction. **