Just tried out Darius/Pyke bot and it was legit the best time I've ever had in that lane. I used to main top, then migrated to support, then back to top the last couple months. I have a pal I constantly queue with, I go top she goes mid. We decided to experiment today and it went fantastic.
Enemy adc was always down 30+ CS, bot lane ganks became triple kills for free (or at worst, 3 for 1). Double relic shield meant my support > enemy support, all the time.
It was super fun and I recommend others try it if they got duo partners willing.