Dark harvest is being ruined because of 1 champion?

Ive been using the rune a little bit on multiple champions such as {{champion:64}} {{champion:141}} {{champion:121}} {{champion:421}} however the damage always seems to be lackluster. After spending a lot of time on DH with reksai, i switched over to electrocute and the damage in 1 game was more than i had seen in the games i was using DH. By the time DH becomes useful, you'd need well over 10-15 stacks from it. Despite this, Karthus seems to thrive with the rune and is the only champion i see really maximizing its effect.

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