Does moving the LoL files from C drive to D or anyother drive mess up the game?

Does it cause any problem.. Im running out of space on my main drive so i just wanted to move files and the lol file is like 18gb.
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We're testing a new feature that gives the option to view discussion comments in chronological order. Some testers have pointed out situations in which they feel a linear view could be helpful, so we'd like see how you guys make use of it.

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