Keyboard and Mouse stop Registering as soon as game loads

Hello, My keyboard and mouse work just fine...I can sign in and choose a game and my champion, navigate the play menus, yet as soon as the game and map load, nothing registers anymore. When I'm on the rift, my mouse moves around, although it doesn't have the glove icon just the standard mouse point, but nothing will click or register with the game, I can't click on the store, I can't move off the spawn point etc. It's very odd, because my keyboard and mouse work everywhere except in game, for instance, they are working just fine typing this out now
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