A few players are reporting issues interacting with the game during a match, or unable to use their mouse or keyboard. The culprit here seems to be Discord Overlays.
Disabling Discord Overlays should fix this up!
Be super wary about apps and modifications, they can be prone to cause issues and are not something we support. More info on our stance for [third party apps](https://support.riotgames.com/hc/en-us/articles/225266848). Stay safe friends!