Who is the biggest threat to Runeterra?

I mean you got a bunch of potentially world ending things happening. But 3 seem to jump out. The Darkin, the Void/Frozen Watchers and Mordekaiser. Nigh-immortal and really pissed off former Ascended. Alien threat from beyond. And a necromancer conqueror who has already taken over the world like twice and currently rules some form of afterlife. So, who do you think is the biggest danger to the world?
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