What are these runes Ryze talks about?

I just watched the cinematic and it has me wondering, what are these runes and how do they play a role in the history of league? Are they kind of like the infinity stones? Are they left overs from the rune wars(assuming thats still a thing in leagues history, I came after so I dont really know)? Im a tad bit confuzled and would love an explanation on what they are.
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