I've had this issue quite a bit, but usually i can just fix it by closing processes that are still running in the task manager. This time, however, I literally couldn't open the client after a restart (currently being forced to reinstall via Hextech repair tool). Is anyone else having this issue, or something similar? I would like to add that I could still open and play the PBE, just not the Live game.
16 gb ddr4 memory
(I can edit in more if needed)