What are some nastiest matchups that can make people regret living?

By nastiest I mean being zoned hard, countered by entire kit of enemy and being forced to play under tower or just being irrelevant for a whole game just because of some feature enemy champ has. One of these that comes to mind is {{champion:114}} vs old (and probably a new one as well){{champion:80}} . In late game fiora destroyed panth but laning phase was hell. What are some disgusting matchups?
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